Crispr-Cas9: our genome-editing future is here

Pretty decent and not overly breathless Wired article here:
http://www.wired.com/2015/07/crispr-dna-editing-2/

Radiolab ep:
http://www.radiolab.org/story/antibodies-part-1-crispr/

Basically I am utterly fascinated by Crispr and within a decade or two it will likely be fundamentally altering our relationship with the biosphere and our own health.

crispr

really

Excellent article, thanks!

crispr

really

― j., Saturday, August 1, 2015 1:23 PM (3 hours ago) Bookmark Flag Post Permalink

i know...

Gonna be kids named Crisper by the year's end.

crisper glovin

https://www.washingtonpost.com/news/wonk/wp/2017/06/13/how-one-company-plans-to-change-your-mind-about-genetically-edited-food/

so uh you guys know where I live and what industry I work in, right

So you're the guy

Can you genetically engineer stuff like Dinty Moore to be edible.

there are many things you can eat that aren't food

not sure whether I'm glad or scared that they left my workplace's impending corporate restructuring off the article

yo have u got any like spare mice with ears growing on their backs that glow in the dark? those things are rad

willing to pay for shipping, hit me up

yeah this is 100% a plant operation, that's someone else's thing

yo have you got any like spare corn with

^ gets it

I can only allocate computing resources, and not very good ones

on my more useful days I see some data that has ATCG in it, but I am told if I rearrange the letters I am not, in fact, doing science

wow science must be harder than i realised i guess

BTW, CRISPR is definitely not ready for clinical use for any but the most debilitating genetic defects.

CRISPR Gene Editing Can Cause Hundreds of Unintended Mutations

In the new study, the researchers sequenced the entire genome of mice that had undergone CRISPR gene editing in the team’s previous study and looked for all mutations, including those that only altered a single nucleotide.

The researchers determined that CRISPR had successfully corrected a gene that causes blindness, but ... found that the genomes of two independent gene therapy recipients had sustained more than 1,500 single-nucleotide mutations and more than 100 larger deletions and insertions. None of these DNA mutations were predicted by computer algorithms that are widely used by researchers to look for off-target effects.

wow science must be harder than i realised i guess

oh yeah they grow plants from scratch, nobody's editing anything that's already growing

I personally eat all the rejected seed though, I will let you know how that goes

maybe you'll be rewarded with superpowers, eg the proportionate strength and speed of a stalk of corn

as tall as an elephant's eye by the fourth of july

imo it's a good thing they didn't try to put genetic material in humans they way they first tried with plants

https://en.wikipedia.org/wiki/Gene_gun#Gene_gun_design

The gene gun was originally a Crosman air pistol modified to fire dense tungsten particles. It was invented by John C Sanford, Ed Wolf and Nelson Allen at Cornell University,[1][2][3] and Ted Klein of DuPont, between 1983 and 1986. The original target was onions (chosen for their large cell size) and it was used to deliver particles coated with a marker gene.[4]

i'm picturing a bunch of guys in lab coats taking it in turns to fire a pistol at an onion with a target painted on it

from what I hear, that is not far off

potentially of course a monster movie is crispr but atthe same time think of the possible benefits if we can play with DNA in this we - we ourselves will be Ridley scott's' architects in prometheus.

that is an awesome responsibility