epigenetics

I'm fascinated by this. lamarck was right?

http://scienceblog.com/48584/your-dna-may-carry-a-%E2%80%98memory%E2%80%99-of-your-living-conditions-in-childhood/

ILX, what do you know? fill my brain. methylate my DNA.

lemme get back to you on this

See: thrifty phenotype hypothesis. From the transcript of this awesome lecture in an amazing series of mind-blowing lectures:

So the point about thrifty phenotypes is this: Early life events are failing to predict late life environments. Perhaps they used to be good predictors, or perhaps those early life events were correlated well with the environment in the Pleistocene, for ten or fifteen years, something like that.

What we do know is this: if you nutritionally stress a mother and infant, the fetuses and infants will have increased risk of obesity, diabetes and cardiovascular disease fifty or sixty years later. And the initial data that demonstrated this came from the Dutch Hungry Winter.

The idea is that stress early in life is switching the individual into a physiology that's very effective at conserving energy, but it is inappropriate if there's an adequate diet. So the muscle cells become insulin resistant, fat becomes concentrated in special depots. And we now have a lot of data indicating that this is the case in humans. So they come from the Dutch Hungry Winter of '44/'45, when the Nazis basically cut off the food supply to Amsterdam, and actually to much of Holland.

has the next gen of sequencers come out yet, I stopped following this shit abt a year ago

Hi this is what the people I work with study. We just put in a big grant app on this in conjunction with one of the unis mentioned.

how do i follow this?

have it be your job is one way

Yeah, that. I don't want to talk too much about work in detail on here but I will send u some interesting names and stuff to look into dayo.

thanks ENBB!

weirdly this was what I worked on during my two-year stint as a lab intern: running methylation-specific PCR on samples from high-risk women at the breast cancer clinic, looking for correlation of methylation w/ cell counts and pre-cancerous changes. sort of hated labwork and decided not to go into the sciences, but it was a pretty cool experience + probably one of the few 'positive contributions 2 society' I will ever make in my life

Most of the stuff the dept I work in studies has to do with this in regards to obesity, btw. There's a really large scale study underway here that, in part, focuses on the epidemiological aspects of obesity coming from a life course approach to chronic disease.

Is it true that people who've been suggest banned have 51 chromosomes?

I Love Too Much (Genetic) Information

It's all about environmental interplay is what I'm told. My dept do a good Behavioral Genetics course, I'm not to read genetics up though. There was a good BBC Horizon a couple of years back;
https://www.youtube.com/watch?v=toRIkRa1fYU